GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs2275426 | 1 | rs12049588 | chr1:46472422 | MUTYH | chr1:45794915-45806142:- | 0.13 | 5.07 | 4.6E-7 | Body mass index |
| BRCA | cis | rs13014235 | 1 | rs12052257 | chr2:202241594 | ALS2CR12 | chr2:202153148-202222101:- | 0.18 | 4.82 | 1.64E-6 | Basal cell carcinoma |
| BRCA | cis | rs2382817 | 1 | rs12053514 | chr2:219167965 | GPBAR1 | chr2:219125738-219128582:+ | 0.12 | 4.17 | 3.27E-5 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |
| BRCA | cis | rs2382817 | 1 | rs12053514 | chr2:219167965 | TMBIM1 | chr2:219138917-219157280:- | -0.13 | -3.91 | 9.99E-5 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |
| BRCA | cis | rs1933488 | 1 | rs12055786 | chr6:153431125 | RGS17 | chr6:153332041-153452389:- | -0.11 | -3.38 | 0.000758 | Prostate cancer |
| BRCA | cis | rs7544256 | 1 | rs12075799 | chr1:115826112 | AMPD1 | chr1:115215722-115238176:- | -0.12 | -4 | 6.64E-5 | Migraine |
| BRCA | cis | rs1144333 | 1 | rs12082448 | chr1:76353225 | ACADM | chr1:76190043-76229353:+ | -0.21 | -4.19 | 2.96E-5 | Attention function in attention deficit hyperactive disorder |
| BRCA | cis | rs75565482 | 1 | rs12097357 | chr1:168468931 | BLZF1 | chr1:169337194-169365778:+ | 0.15 | 3.57 | 0.000373 | Emphysema imaging phenotypes |
| BRCA | cis | rs12101261 | 1 | rs12101255 | chr14:81451052 | TSHR | chr14:81421869-81612646:+ | -0.12 | -3.59 | 0.000348 | Graves' disease |
| BRCA | cis | rs12107539 | 1 | rs12107539 | chr3:151042464 | P2RY14 | chr3:150929905-150996230:- | -0.08 | -3.54 | 0.000411 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |
| BRCA | cis | rs7627289 | 1 | rs12107673 | chr3:167454002 | SERPINI1 | chr3:167453432-167543356:+ | 0.13 | 3.42 | 0.000642 | Visceral fat |
| BRCA | cis | rs6684514 | 1 | rs12117903 | chr1:156311165 | BGLAP | chr1:156182784-156213112:+ | 0.19 | 5.05 | 5.16E-7 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs12117903 | chr1:156311165 | CCT3 | chr1:156278752-156308195:- | -0.11 | -3.63 | 0.000301 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs12117947 | chr1:156244058 | BGLAP | chr1:156182784-156213112:+ | 0.21 | 5.57 | 3.26E-8 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs12117951 | chr1:156305286 | BGLAP | chr1:156182784-156213112:+ | 0.19 | 5.04 | 5.36E-7 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |